Abstract:Vulnerability is an important criterion to assess the ethical justification of the inclusion of participants in research trials. Currently, vulnerability is often understood as an attribute inherent to a participant by nature of a diagnosed condition. Accordingly, a common ethical concern relates to the participant’s decisionmaking capacity and ability to provide free and informed consent. We propose an expanded view of vulnerability that moves beyond a focus on consent and the intrinsic attributes of participants. We offer specific suggestions for how (...) relational aspects and the dynamic features of vulnerability could be more fully captured in current discussions and research practices. (shrink)

Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology, and the context in which measurements are made. Recent advances provide important opportunities to identify and address the key questions in the field. By bringing together (...) researchers from different areas of biology and biomedicine, we describe and evaluate these developments and the insights they could yield, highlighting the need for more standardisation across disciplines. We conclude with a list of important questions that can now be addressed by developing a common conceptual and methodological toolkit for studies on metabolic variation in animals. (shrink)

In the UK, current policies and services for people with mental disorders, including those with intellectual disabilities (ID), presume that these men and women can, do, and should, make decisions for themselves. The new Mental Capacity Act (England and Wales) 2005 (MCA) sets this presumption into statute, and codifies how decisions relating to health and welfare should be made for those adults judged unable to make one or more such decisions autonomously. The MCA uses a procedural checklist to guide this (...) process of substitute decision-making. The personal experiences of providing direct support to seven men and women with ID living in residential care, however, showed that substitute decision-making took two forms, depending on the type of decision to be made. The first process, ‘strategic substitute decision-making’, paralleled the MCA’s legal and ethical framework, whilst the second process, ‘relational substitute decision-making’, was markedly different from these statutory procedures. In this setting, ‘relational substitute decision-making’ underpinned everyday personal and social interventions connected with residents’ daily living, and was situated within a framework of interpersonal and interdependent care relationships. The implications of these findings for residential services and the implementation of the MCA are discussed. (shrink)

The advances in treatment of HIV and the introduction of polymerase chain reaction assay for the virus now make it acceptable for HIV discordant couples where the male partner is seropositive to attempt to conceive through artificial insemination by husband (AIH) or via in vitro fertilisation. With undetectable viral load and washed sperm, there is minimal risk of transmission of HIV to the female partner, children, other patients, or staff. We describe the development of a programme of AIH for HIV (...) discordant couples and the reasoning behind offering such a programme. (shrink)

Given classical (2 valued) structures and and a homomorphism h of onto , it is shown how to construct a (non-degenerate) 3-valued counterpart of . Classical sentences that are true in are non-false in . Applications to number theory and type theory (with axiom of infinity) produce finite 3-valued models in which all classically true sentences of these theories are non-false. Connections to relevant logic give absolute consistency proofs for versions of these theories formulated in relevant logic (the proof for (...) number theory was obtained earlier by R. K. Meyer and suggested the present abstract development). (shrink)

Taking account of crucial differences between the social environments of universities in Newman 's time and in ours, this paper considers two key concepts in the "The Idea of the University", the 'philosophical' and the 'liberal'. It argues that, despite their merits, both concepts are beset by problems. And it suggests some lines of analysis, partly inspired by an Aristotelian influence both in Newman 's own work and in some recent philosophy, that may help to address these problems and to (...) support claims for the continuing power of Newman 's thinking about university education. (shrink)

This book is a specialized monograph on the development of the mathematical and computational metatheory of reductive logic and proof-search, areas of logic that are becoming important in computer science. A systematic foundational text on these emerging topics, it includes proof-theoretic, semantic/model-theoretic and algorithmic aspects. The scope ranges from the conceptual background to reductive logic, through its mathematical metatheory, to its modern applications in the computational sciences. Suitable for researchers and graduate students in mathematical, computational and philosophical logic, and in (...) theoretical computer science and artificial intelligence, this is the latest in the prestigous world-renowned Oxford Logic Guides, which contains Michael Dummet's Elements of intuitionism, Dov M. Gabbay, Mark A. Reynolds, and Marcelo Finger's Temporal Logic Mathematical Foundations and Computational Aspects, J. M. Dunn and G. Hardegree's Algebraic Methods in Philosophical Logic, H. Rott's Change, Choice and Inference: A Study of Belief Revision and Nonmonotonic Reasoning, and P. T. Johnstone's Sketches of an Elephant: A Topos Theory Compendium: Volumes 1 and 2. (shrink)

Environmental ethics has traditionally focused on a defense of the intrinsic value of animals and wild habitats. However, this ethical project needs to be supplemented by a consideration of the kind of culture that can take such an ethical point of view seriously. This essay argues that one component of an environmentally responsible culture is its domesticated environment. How we construct the domesticated environment has an impact on our perception of our own identities and our relations to wild nature. If (...) we care about wild nature, we must also care about the domesticated environment in which we live our lives. This essay contributes to an ethical reflection on the need to overcome the traditional dualism between domesticated and wild, built and natural that permeates environmental ethical thinking. (shrink)

Environmental ethics has traditionally focused on a defense of the intrinsic value of animals and wild habitats. However, this ethical project needs to be supplemented by a consideration of the kind of culture that can take such an ethical point of view seriously. This essay argues that one component of an environmentally responsible culture is its domesticated environment. How we construct the domesticated environment has an impact on our perception of our own identities and our relations to wild nature. If (...) we care about wild nature, we must also care about the domesticated environment in which we live our lives. This essay contributes to an ethical reflection on the need to overcome the traditional dualism between domesticated and wild, built and natural that permeates environmental ethical thinking. (shrink)

quidnam homines putarent, si turn occisus esset, cum tu ilium in foro inspectante populo Romano gladio insecutus es negotiumque transegisses, nisi se ille in scalas tabernae librariae coniecisset iisque oppilatis impetum tuum compressisset?

As generally interpreted this line leaves much to be desired because of its unwieldy construction. It is true that est ut plus a form of possum is a common periphrasis in Lucretius . Quite common also is Lucretius' use of the infinitive as a nominative substantive . But the combination of fieri mirarier with the already periphrastic erat ut posset results in ‘a very clumsy phrase.… The line should be regarded as one which Lucretius might have improved on revision’.

This book is a specialized monograph on the development of the mathematical and computational metatheory of reductive logic and proof-search, areas of logic that are becoming important in computer science. A systematic foundational text on these emerging topics, it includes proof-theoretic, semantic/model-theoretic and algorithmic aspects. The scope ranges from the conceptual background to reductive logic, through its mathematical metatheory, to its modern applications in the computational sciences. Suitable for researchers and graduate students in mathematical, computational and philosophical logic, and in (...) theoretical computer science and artificial intelligence, this is the latest in the prestigous world-renowned Oxford Logic Guides, which contains Michael Dummet's Elements of intuitionism (2nd Edition), Dov M. Gabbay, Mark A. Reynolds, and Marcelo Finger's Temporal Logic Mathematical Foundations and Computational Aspects, J. M. Dunn and G. Hardegree's Algebraic Methods in Philosophical Logic, H. Rott's Change, Choice and Inference: A Study of Belief Revision and Nonmonotonic Reasoning, and P. T. Johnstone's Sketches of an Elephant: A Topos Theory Compendium: Volumes 1 and 2. (shrink)

All commentators on these lines make two assumptions about the first clause, that means ‘sitting in judgement’, ‘punishing’, or the like, that the which is its subject as well as that of is the second in a series of two: the subsequent slaying punishes or sits in judgement on the previous; thus the slaying of Cly taemnestra herself will sit in judgement upon that of Agamemnon, just as that had sat in judgement upon the of Iphigenia. Then opinions differ as (...) to whether is to be taken as the object of both verbs, or of one but not the other. (shrink)

Barrett finds lines 1010–15 difficult. He says that ‘hovers between “an heiress as my wife” and “marriage with an heiress”’, that ‘a Greek heiress did not inherit property as her own: it passed not to her but with her, to her husband and ultimately to her children.—In Attic law a widow was never : a man's property went to his legitimate children.